Common dihydrofolate reductase 19–base pair deletion allele: a novel risk factor for preterm delivery
نویسندگان
چکیده
منابع مشابه
Common dihydrofolate reductase 19-base pair deletion allele: a novel risk factor for preterm delivery.
BACKGROUND Folate is critical for cell division, a major feature of in utero development. Dihydrofolate reductase (DHFR) is required to convert the folic acid used in supplements and for food fortification and the dihydrofolate produced by thymidylate synthase during DNA synthesis to the reduced folate forms used by the cell. OBJECTIVE We aimed to determine whether a common, recently discover...
متن کاملA functional 19-base pair deletion polymorphism of dihydrofolate reductase (DHFR) and risk of breast cancer in multivitamin users.
BACKGROUND Dihydrofolate reductase (DHFR) converts dihydrofolate (DHF) into tetrahydrofolate (THF) and plays an essential role in cell metabolism and cellular growth. Folic acid from multivitamins needs to be reduced by DHFR before it participates in cellular reactions. OBJECTIVES We examined the relation of a 19-base pair (bp) deletion polymorphism of the DHFR gene with the risk of breast ca...
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ژورنال
عنوان ژورنال: The American Journal of Clinical Nutrition
سال: 2005
ISSN: 0002-9165,1938-3207
DOI: 10.1093/ajcn/81.3.664